Which drug is recognized for its interaction with Vitamin D affecting calcium absorption?

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Multiple Choice

Which drug is recognized for its interaction with Vitamin D affecting calcium absorption?

The main concept is that some drugs can alter vitamin D metabolism, changing how well calcium is absorbed from the gut. Phenytoin, an antiseizure medication, induces hepatic enzymes that increase the breakdown of vitamin D. With less active vitamin D available, calcium absorption from the intestines drops, which can lower calcium levels and over time contribute to bone mineral loss. This is why phenytoin is recognized for this interaction. Digitalis and hydralazine don’t have a clinically meaningful effect on vitamin D activation or calcium absorption, so they don’t share this specific interaction. Therefore, the correct choice is the drug that shows this vitamin D–calcium absorption interaction.

The main concept is that some drugs can alter vitamin D metabolism, changing how well calcium is absorbed from the gut. Phenytoin, an antiseizure medication, induces hepatic enzymes that increase the breakdown of vitamin D. With less active vitamin D available, calcium absorption from the intestines drops, which can lower calcium levels and over time contribute to bone mineral loss. This is why phenytoin is recognized for this interaction.

Digitalis and hydralazine don’t have a clinically meaningful effect on vitamin D activation or calcium absorption, so they don’t share this specific interaction. Therefore, the correct choice is the drug that shows this vitamin D–calcium absorption interaction.

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